Seven technologies to watch in 2022


The Telomere-to-Telomere Consortium is sequencing whole chromosomes.Credit: Adrian T. Sumner/SPL

From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead.

Fully finished genomes

Roughly one-tenth of the human genome remained uncharted when genomics researchers Karen Miga at the University of California, Santa Cruz, and Adam Phillippy at the National Human Genome Research Institute in Bethesda, Maryland, launched the Telomere-to-Telomere (T2T) consortium in 2019. Now, that number has dropped to zero. In a preprint published in May last year, the consortium reported the first end-to-end sequence of the human genome, adding nearly 200 million new base pairs to the widely used human consensus genome sequence known as GRCh38, and writing the final chapter of the Human Genome Project1.

First released in 2013, GRCh38 has been a valuable tool — a scaffold on which to map sequencing reads. But it’s riddled with holes. This is largely because the widely used sequencing technology developed by Illumina, in San Diego, California, produces reads that are accurate, but short. They are not long enough to unambiguously map highly repetitive genomic sequences, including the telomeres that cap chromosome ends and the centromeres that coordinate the partitioning of newly replicated DNA during cell division.

Long-read sequencing technologies proved to be the game-changer. Developed by Pacific Biosciences in Menlo Park, California, and Oxford Nanopore Technologies (ONT) in Oxford, UK, these technologies can sequence tens or even hundreds of thousands of bases in a single read, but — at least at the outset — not without errors. By the time the T2T team reconstructed2,3 their first individual chromosomes — X and 8 — in 2020, however, Pacific Biosciences’ sequencing had advanced to the extent that T2T scientists could detect tiny variations in long stretches of repeated sequences. These subtle ‘fingerprints’ made long repetitive chromosome segments tractable, and the rest of the genome quickly fell into line. The ONT platform also captures many modifications to DNA that modulate gene expression, and T2T was able to map these ‘epigenetic tags’ genome-wide as well4.

The genome T2T solved was from a cell line that contains two identical sets of chromosomes. Normal diploid human genomes contain two versions of each chromosome, and researchers are now working on ‘phasing’ strategies that can confidently assign each sequence to the appropriate chromosome copy. “We’re already getting some pretty phenomenal phased assemblies,” says Miga.

This diploid assembly work is being conducted in collaboration with T2T’s partner organization, the Human Pangenome Reference Consortium, which aspires to produce a more representative genome map, based on hundreds of donors from around the world. “We’re aiming to capture an average of 97% of human allelic diversity,” says Erich Jarvis, one of the consortium’s lead investigators and a geneticist at the Rockefeller University in New York City. As chair of the Vertebrate Genomes Project, Jarvis also hopes to leverage these complete genome assembly capabilities to generate full sequences

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Worker Roasts Buyers Who Check Out Groceries at Electronics

A Walmart employee is putting prospects on blast for striving to verify out their groceries in the electronics area of the retail store, sparking a debate in the comments part of the TikTok.

The movie was posted by @benji.2x on Jan.4, and it has racked up 1.3 million views since then. The online video attributes textual content overlay that reads, “When a purchaser with a whole cart of groceries attempts to check out at electronics.”

The TikToker mouths the terms to J. Cole’s “Love Yourz,” essentially telling customers that when they “came a prolonged way,” they “went the incorrect way.”

“Gonna have to go to the entrance,” the textual content overlay reads as the TikToker factors them in the ideal course.

“im not ringing up $300 worthy of of food items,” the caption of the video states.

https://www.tiktok.com/@benji.2x/movie/7049565215117298990

Some clear hypermarket workers chimed in by using the remarks segment. “I notify them we do not have a weigher then they are like okay we just won’t obtain the vegetables any longer and give it to me to put back,” a person commenter wrote. “I walk away.”

An additional worker claimed shoppers have long gone as considerably as to try out examining out in the fitting rooms.

“People have tried out to pay at the fitting space we really don’t even have a sign-up,” the commenter wrote.

Some customers expressed comparable irritation, indicating that they have experimented with to use the electronics checkout at their spot to acquire a thing from the office but located that the cashier was occupied by an additional shopper with non-digital items.

“No for genuine like I’ll be making an attempt to get a charger and I can not simply because an individual with 20 matters won’t give y’all the time to,” one particular wrote.

Even now, some commenters who look to spend for their groceries at the electronics counter defended the act.

“If I’m becoming pressured to pay out for my electronic just before I depart the electronic portion y’all are gonna ring up these groceries much too,” one commenter wrote.

With regards to his personal keep, @Benji.2x shared in a comment that he prioritizes electronics division customers.

The Daily Dot reached out to @benji.2x by way of a TikTok direct information and a comment on the video, as perfectly as to Walmart.

Will have to-reads on the Day by day Dot

*To start with Posted: Jan 26, 2022, 8:50 am CST

Brooke Sjoberg

Brooke Sjoberg

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The best cheap gaming headset deals January 2022

A good gaming headset is practically a necessity these days. Clean and precise audio is essential for competitive gaming, allowing you not just to pinpoint your enemies, but communicate effectively with your teammates. Moreover, recent developments in spatial audio and virtual surround sound have allowed headsets to meet — and occasionally surpass — more expensive audio setups, allowing even the most budget-conscious gamer to obtain a competitive edge at a fraction of the price.

While you could always invest in a massive pair of speakers, they’re likely to earn you the dubious distinction of the worst roommate of the decade. Thankfully, the right headset will allow you to keep the running and gunning to yourself, which is why we’ve rounded up a collection of the best deals you can currently find on some of our favorite models.

For the sake of clarity, we’ve broken the deals down into two categories: wireless and wired. The former is tailored toward gamers looking for a little less clutter in their setup, while the latter is aimed at anyone who doesn’t mind a little extra cabling, or is looking for a headset that’s a little more budget-friendly.

The best wireless gaming headset deals

Logitech G435

Compatible with PC, PS4, PS5, Nintendo Switch

Definitely the boldest headset on our list, the Logitech G435 is a gaming headset perfect for anyone that isn’t afraid to make a statement. This comfortable, colorful headset is available in the blue colorway at Amazon and Walmart for $59, a modest $21 discount.

This on-ear headset has both Bluetooth and 2.4Ghz wireless connectivity, making it compatible with PCs in addition to consoles and mobile devices. The 18-hour battery life is impressive, too, and while it does lack the more traditional 3.5mm audio jack, the included USB-C cable can be used to simultaneously charge and listen.

While the lightweight headset lacks the prevalent boom-mic design used by other headsets in this category — it opts for beamforming microphones — the integrated mic still manages to provide an adequate audio input solution. This has the added benefit of giving the headset a more traditional, on-ear profile, giving you the option of wearing these in public without broadcasting your gamer status.


Logitech G435 Lightspeed

Logitech’s G435 Lightspeed is a lightweight and comfortable wireless gaming headset that won’t break the bank. It’s compatible with PlayStation consoles, as well as the Nintendo Switch and PC. It also supports Bluetooth, so you can listen to music or pick up calls while you game.

Razer BlackShark V2 Pro

Compatible with PC, PS4, PS5, Xbox Series X/S, Nintendo Switch (via 3.5mm audio)

The wireless version of the esports-inspired BlackShark headset from Razer boasts a lightweight, aviator design, and is currently discounted to $139.99 at Gamestop and $149.99 at Amazon. This isn’t the lowest price we’ve seen the comfortable headset go for, but it remains a solid discount on an excellent gaming headset that normally retails for $179.99.

The Razer BlackShark V2 Pro is sturdy and perfectly suited for

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A new language for quantum computing | MIT News

Time crystals. Microwaves. Diamonds. What do these three disparate points have in frequent? 

Quantum computing. Compared with common desktops that use bits, quantum computers use qubits to encode information as zeros or types, or both of those at the exact time. Coupled with a cocktail of forces from quantum physics, these fridge-sized equipment can method a entire good deal of data — but they are significantly from flawless. Just like our regular desktops, we will need to have the correct programming languages to properly compute on quantum desktops. 

Programming quantum computer systems needs consciousness of a little something called “entanglement,” a computational multiplier for qubits of sorts, which translates to a great deal of electric power. When two qubits are entangled, actions on just one qubit can adjust the benefit of the other, even when they are bodily separated, supplying rise to Einstein’s characterization of “spooky motion at a length.” But that efficiency is equivalent elements a source of weakness. When programming, discarding one particular qubit without having currently being aware of its entanglement with a further qubit can destroy the knowledge stored in the other, jeopardizing the correctness of the application. 

Experts from MIT’s Personal computer Science and Synthetic Intelligence (CSAIL) aimed to do some unraveling by creating their possess programming language for quantum computing named Twist. Twist can describe and verify which pieces of facts are entangled in a quantum software, by a language a classical programmer can understand. The language makes use of a concept named purity, which enforces the absence of entanglement and success in much more intuitive programs, with preferably much less bugs. For instance, a programmer can use Twist to say that the non permanent details created as garbage by a system is not entangled with the program’s remedy, earning it risk-free to throw away.

Whilst the nascent industry can feel a minimal flashy and futuristic, with images of mammoth wiry gold devices coming to brain, quantum computer systems have opportunity for computational breakthroughs in classically unsolvable duties, like cryptographic and interaction protocols, look for, and computational physics and chemistry. One of the important worries in computational sciences is dealing with the complexity of the dilemma and the amount of money of computation desired. Whilst a classical electronic laptop would need to have a pretty significant exponential quantity of bits to be able to method such a simulation, a quantum laptop or computer could do it, perhaps, applying a really tiny quantity of qubits — if the suitable programs are there. 

“Our language Twist will allow a developer to publish safer quantum packages by explicitly stating when a qubit should not be entangled with a further,” claims Charles Yuan, an MIT PhD university student in electrical engineering and computer system science and the lead writer on a new paper about Twist. “Because understanding quantum courses needs knowing entanglement, we hope that Twist paves the way to languages that make the distinctive troubles of quantum computing more obtainable to programmers.” 

Yuan wrote the paper together

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